NO synthase isoforms specifically modify peroxynitrite reactivity
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چکیده
منابع مشابه
O-8: Study of Peroxynitrite Levels, Arginase Activity and NO Synthase Activity in Seminal Plasma of Iraqi Leukocytospermic Patients
Background Leukocytes linked directly and indirectly to reactive oxygen species (ROS) formation. Although leukocytospermia is defined as the presence of ≥1×106 white blood cells/mL (WBC/mL) in a semen sample, the presence of less than 1×106 WBC/mL (low-level leukocytospermia) still can produce a detectable amount of ROS, impairing sperm function and lowering the chances of pregnancy. Low concen...
متن کاملDifferent Vasculoprotective Roles of NO Synthase Isoforms in Vascular Lesion Formation
NO is known to have several important vasculoprotective actions. Although NO is synthesized by 3 different NO synthase (NOS) isoforms, the vasculoprotective action of individual NOS isoforms remains to be clarified. Permanent ligation of the left common carotid artery was performed in control, endothelial NOS (eNOS) knockout (eNOS-KO), and inducible NOS (iNOS) knockout (iNOS-KO) mice. Four week...
متن کاملBiphasic response of cardiac NO synthase isoforms to ischemic preconditioning in conscious rabbits.
In conscious rabbits, a sequence of six 4-min coronary occlusion/4-min reperfusion cycles, which elicits late preconditioning (PC), caused rapid activation of calcium-dependent nitric oxide (NO) synthase (NOS) [cNOS; endothelial NOS (eNOS) and/or neuronal NOS (nNOS)], whereas calcium-independent NOS [inducible NOS (iNOS)] activity remained unchanged. The enhanced cNOS activity was associated wi...
متن کاملChanges in the expression of NO synthase isoforms after ozone: the effects of allergen exposure
BACKGROUND The functional role of nitric oxide (NO) and various nitric oxide synthase (NOS) isoforms in asthma remains unclear. OBJECTIVE This study investigated the effects of ozone and ovalbumin (OVA) exposure on NOS isoforms. METHODS The expression of inducible NOS (iNOS), neuronal NOS (nNOS), and endothelial NOS (eNOS) in lung tissue was measured. Enhanced pause (Penh) was measured as a...
متن کاملAge dependent expression and distribution of nitric oxide (NO) synthase isoforms in the ovine kidney
The aim of the present study was to measure intrarenal spatial and temporal localization of all three nitric oxide synthase (NOS) isoforms in the developing ovine kidney. Reverse transcriptase-polymerase chain reaction (RT-PCR), Western Blot analyses, and in situ hybridization techniques were performed for NOS I III isoforms in renal tissue obtained from sheep aged ~24 h, one, three, six, and 1...
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ژورنال
عنوان ژورنال: FEBS Journal
سال: 2010
ISSN: 1742-464X
DOI: 10.1111/j.1742-4658.2010.07786.x